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Long-term studies in animals to evaluate the carcinogenic potential of Acetazolamide have not been conducted. Acetazolamide should only be used by nursing women if the potential benefit justifies the potential risk to the child. Some of the problems associated include low aqueous solubility, poor permeability, erratic and poor absorption, inte … a potent carbonic anhydrase inhibitor. Adverse reactions common to all sulfonamide derivatives may occur: anaphylaxis, fever, rash (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), crystalluria, renal calculus, bone marrow depression, thrombocytopenic purpura, hemolytic anemia, leukopenia, pancytopenia and agranulocytosis. Acetazolamide is also used to treat certain types of seizures , and to treat or prevent altitude sickness. Most commonly, these are generic drugs. Acetazolamide can pass into breast milk and may harm a nursing baby. Acetazolamide is used with other medicines to reduce edema (excess fluid retention) and to help control seizures in certain types of epilepsy. Acetazolamide is a prescription medication used to treat glaucoma and symptoms of acute mountain sickness. Form. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Continuous supervision by a physician is advisable. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Acetazolamide may also be used for purposes not listed in this medication guide. Acetazolamide (Diamox) Therapeutic Class. Methazolamide belongs to a class of drugs known as carbonic anhydrase inhibitors. Be careful if you drive or do anything that requires you to be alert. Avoid exposure to sunlight or tanning beds. Written by Cerner Multum. This product's label may have been updated. In a bacterial mutagenicity assay, Acetazolamide was not mutagenic when evaluated with and without metabolic activation. Acetazolamide belongs to a class of drugs called Anticonvulsants, Other; Antiglaucoma, Carbonic Anhydrase Inhibitors. Call your doctor for medical advice about side effects. Acetazolamide systemic 250 mg (5430 DAN DAN). Acetazolamide should be used as an adjunct to the usual therapy. Your dose of this medicine will depend on the condition you are treating. If significant changes occur, early discontinuance and institution of appropriate therapy are important. Call your doctor for medical advice about side effects. BCS class IV drugs (e.g., amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel) exhibit many characteristics that are problematic for effective oral and per oral delivery. ACETAZOLAMIDE CLASS: Anticonvulsant, Miscellaneous; Carbonic Anhydrase Inhibitor; Diuretic, Carbonic Anhydrase Inhibitor; Ophthalmic Agent, Antiglaucoma INDICATIONS: Treatment of glaucoma (chronic simple open-angle, secondary glaucoma, preoperatively in acute angle-closure); drug-induced edema or edema While using acetazolamide, you may need frequent blood tests. Acetazolamide is an enzyme inhibitor that acts specifically on carbonic anhydrase, the enzyme that catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. Each 500 mg vial containing sterile Acetazolamide sodium should be reconstituted with at least 5 mL of Sterile Water for Injection prior to use. Acetazolamide is used with other medicines to reduce edema (excess fluid retention) and to help control seizures in certain types of epilepsy. Generic Name: Acetazolamide sodium Most commonly, these are "preferred" (on formulary) brand drugs. Regulatory Classification. If signs of hypersensitivity or other serious reactions occur, discontinue use of this drug. Acetazolamide is used in people with certain types of glaucoma to reduce the amount of fluid in the eye, which decreases pressure inside the eye. Most commonly, these are "non-preferred" brand drugs. The Harriet Lane Handbook app and website provides pediatric diagnosis and treatment, pediatric management algorithms, and pediatric drug formulary from experts at Johns Hopkins University. Follow all directions on your prescription label. When Acetazolamide is given in combination with other anticonvulsants, it is suggested that the starting dose should be 250 mg once daily in addition to the existing medications. Because of the potential for serious adverse reactions in nursing infants from Acetazolamide, a decision should be made whether to discontinue nursing or to discontinue the drug taking into account the importance of the drug to the mother. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Inhibition of carbonic anhydrase in this area appears to retard abnormal, paroxysmal, excessive discharge from central nervous system neurons. Take the missed dose as soon as you remember. Store at room temperature away from moisture and heat. You may report side effects to FDA at 1-800-FDA-1088. Sensitizations may recur when a sulfonamide is readministered irrespective of the route of administration. Find information on Acetazolamide (Diamox) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Copyright 1996-2021 Cerner Multum, Inc. Acetazolamide is also used as a diuretic ("water pill") in people with congestive heart failure, to reduce the build-up of fluid in the body. You should not use acetazolamide if you have cirrhosis, severe liver or kidney disease, an electrolyte imbalance, adrenal gland failure, or an allergy to acetazolamide or sulfa drugs. Acetazolamide is not a mercurial diuretic. Rather, it is a non-bacteriostatic sulfonamide possessing a chemical structure and pharmacological activity distinctly different from the bacteriostatic sulfonamides. Acetazolamide (Diamox) Mechanism of action-reduction of hydrogen ions and bicarbonate. The direct intravenous route of administration is preferred. The suggested total daily dose is 8 to 30 mg per kg in divided doses. Discard unused portion. Acetazolamide is also used as a diuretic ("water pill") in people with congestive heart failure, to reduce the build-up of fluid in the body. Skip the missed dose if it is almost time for your next scheduled dose. Generic Name: acetazolamide (a SEET a ZOLE a mide)Brand Name: Diamox, Diamox SequelsDosage Forms: oral capsule, extended release (500 mg); oral tablet (125 mg; 250 mg). It is not known if Acetazolamide is safe and effective in children young than 12 years of age. For the reduction of intraocular pressure (IOP), acetazolamide inactivates carbonic anhydrase and interferes with the sodium pump, which decreases aqueous humor formation and thus lowers IOP. Acetazolamide therapy is contraindicated in situations in which sodium and/or potassium blood serum levels are depressed, in cases of marked kidney and liver disease or dysfunction, in suprarenal gland failure, and in hyperchloremic acidosis. You may report side effects to FDA at 1-800-FDA-1088. 4 Species: Acetazolamide is a prescription drug primarily used to treat dogs, cats and horses. Teratogenic Effects: Pregnancy Category C. Acetazolamide, administered orally or parenterally, has been shown to be teratogenic (defects of the limbs) in mice, rats, hamsters, and rabbits. Acetazolamide should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Acetazolamide is an aromatic sulfonamide used as a carbonic anhydrase inhibitor. This condition invariably subsides upon diminution or discontinuance of the medication. loss of movement in any part of your body; a blood cell disorder--sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, pale skin, feeling tired or short of breath, rapid heart rate, nosebleeds, bleeding gums; liver problems--nausea, upper stomach pain or swelling, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); signs of metabolic acidosis--confusion, vomiting, lack of energy, irregular heartbeats; signs of a kidney stone--pain in your side or lower back, blood in your urine, painful or difficult urination; or. For diuresis in congestive heart failure, the starting dose is usually 250 to 375 mg once daily in the morning (5 mg/kg). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Acetazolamide, sold under the trade name Diamox among others, is a medication used to treat glaucoma, epilepsy, altitude sickness, periodic paralysis, idiopathic intracranial hypertension (raised brain pressure of unclear cause), and heart failure. Electrolyte imbalance, development of an acidotic state, and central nervous effects might be expected to occur. The dosage employed in the treatment of chronic simple (open-angle) glaucoma ranges from 250 mg to 1 g of Acetazolamide per 24 hours, usually in divided doses for amounts over 250 mg. Fatalities have occurred although rarely, due to severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia and other blood dyscrasias (see WARNINGS). The diuretic effect of Acetazolamide is due to its action in the kidney on the reversible reaction involving hydration of carbon dioxide and dehydration of carbonic acid. This may be particularly important in the management of Acetazolamide overdosage when complicated by the presence of renal failure. Contains no preservative. For current full prescribing information, please visit www.zydususa.com, gabapentin, furosemide, hydrochlorothiazide, clonazepam, spironolactone, lamotrigine, Lasix, Lyrica, diazepam, topiramate. There are no adequate and well-controlled studies in pregnant women. It facilitates production of alkaline urine with an elevated biocarbonate, sodium, and potassium ion concentrations. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Drug class: Carbonic Anhydrase Inhibitors. Hypersensitivity to Acetazolamide or any excipients in the formulation. Other occasional adverse reactions include urticaria, melena, hematuria, glycosuria, hepatic insufficiency, flaccid paralysis, photosensitivity and convulsions. If you take acetazolamide for congestive heart failure, your doctor may tell you to skip your medication for a day. Acetazolamide (Diamox, Diamox Sequels) used to remove excess fluid in the body in people with congestive heart failure; to treat seizures and glaucoma; and the prevention and treatment of altitude sickness. Adverse reactions, occurring most often early in therapy, include paresthesias, particularly a "tingling" feeling in the extremities, hearing dysfunction or tinnitus, loss of appetite, taste alteration and gastrointestinal disturbances such as nausea, vomiting and diarrhea; polyuria, and occasional instances of drowsiness and confusion. Evidence seems to indicate that Acetazolamide has utility as an adjuvant in treatment of certain dysfunctions of the central nervous system (e.g., epilepsy). Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. acetazolamide may impair your thinking or reactions. The dosage recommendations for glaucoma and epilepsy differ considerably from those for congestive heart failure, since the first two conditions are not dependent upon carbonic anhydrase inhibition in the kidney which requires intermittent dosage if it is to recover from inhibitory effect of the therapeutic agent. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This build-up is called edema. Since acetazolamide is a sulfonamide derivative, cross sensitivity between acetazolamide, sulfonamides and other sulfonamide derivatives is possible. We comply with the HONcode standard for trustworthy health information -, Drug class: carbonic anhydrase inhibitor anticonvulsants, Carbonic anhydrase inhibitor anticonvulsants. Davis Drug … Medically reviewed by Drugs.com. It also treats and prevents symptoms of altitude sickness (acute mountain sickness). In patients with pulmonary obstruction or emphysema where alveolar ventilation may be impaired, Acetazolamide which may precipitate or aggravate acidosis, should be used with caution. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Available for Android and iOS devices. Acetazolamide’s use in small animals is complicated by a relatively high occurrence of adverse effects. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Precaution is advised for early detection of such reactions and the drug should be discontinued and appropriate therapy instituted. Do not use acetazolamide in larger or smaller amounts or for longer than recommended. Acetazolamide, an inhibitor of the enzyme carbonic anhydrase, is a white to faintly yellowish white crystalline, odorless powder, weakly acidic, very slightly soluble in water and slightly soluble in alcohol. No data are available regarding Acetazolamide overdosage in humans as no cases of acute poisoning with this drug have been reported. Store drug product at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. In some acute cases, it may be more satisfactory to administer an initial dose of 500 mg followed by 125 or 250 mg every four hours depending on the individual case. What are the possible side effects of Acetazolamide? Dosage Form: injection, powder, lyophilized, for solution. It is taken by mouth or injection into a vein. Follow your doctor's dosing instructions very carefully. In all cases, the dosage should be adjusted with careful individual attention both to symptomatology and ocular tension. Possible serious side effects include liver problems, seizures, and metabolic acidosis. https://www.cvs.com/drug/acetazolamide/oral-capsule-extended-release/500mg Failures in therapy may be due to overdosage or too frequent dosage. Acetazolamide is an inhibitor of carbonic anhydrase. Increasing the dose often results in a decrease in diuresis. Acetazolamide (Diamox) Version: 5.01. gabapentin, furosemide, hydrochlorothiazide, clonazepam, spironolactone, lamotrigine, Lasix, Lyrica, diazepam, topiramate. It works by decreasing the production of fluid inside the eye. The use of Acetazolamide does not eliminate the need for other therapy such as digitalis, bed rest, and salt restriction. Acetazolamide belongs to a class of drugs known as carbonic anhydrase inhibitors. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Acetazolamide is a sulfonamide derivative with diuretic, antiglaucoma, and anticonvulsant properties. Acetazolamide is also used to treat certain types of seizures, and to treat or prevent altitude sickness. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This drug is available at the lowest co-pay. Available for Android and iOS devices. Acetazolamide is a non-competitive inhibitor of carbonic anhydrase, an enzyme found in cells in the proximal tube of the kidney, the eye, and glial cells. Treatment should be symptomatic and supportive. Acetazolamide. Tell your doctor if you are pregnant or plan to become pregnant. The chemical name for Acetazolamide is N-(5-Sulfamoyl-1,3,4-thiadiazol-2yl)-acetamide and has the following structural formula: Acetazolamide is available for intravenous use, and is supplied as a sterile powder requiring reconstitution. This can be increased to levels as indicated above. The result is renal loss of bicarbonate (HCO 3 … Other drugs may interact with acetazolamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Acetazolamide may be used alone or with other medications. Also see PRECAUTIONS: Information for Patients for possible reactions common to sulfonamide derivatives. Caution is advised for patients receiving concomitant high-dose aspirin and Acetazolamide, as anorexia, tachypnea, lethargy, metabolic acidosis, coma, and death have been reported. This build-up is called edema. nausea, vomiting, loss of appetite, diarrhea; numbness or tingling, especially in your arms and legs; This is not a complete list of side effects and others may occur. Acetazolamide is also used as a diuretic ("water pill") in people with congestive heart failure, to reduce the build-up of fluid in the body. Drug-induced edema 250-375 mg once daily for 1-2 days, alternating w/ a day of rest. For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies (petit mal, unlocalized seizures); chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. The safety and effectiveness of Acetazolamide in children have not been established. acetazolamide A drug that inhibits the enzyme carbonic anhydrase in the kidney tubules, thus acting as a diuretic. Last updated on May 1, 2019. It is contraindicated in patients with cirrhosis because of the risk of development of hepatic encephalopathy. Animal data suggest that Acetazolamide is remarkably nontoxic. ... S01EC01 - acetazolamide ; Belongs to the class of carbonic anhydrase inhibitors. No specific antidote is known. However, some investigators feel that daily doses in excess of 1 g do not produce any better results than a 1 g dose. Blocking this protein can help reduce the build-up of certain fluids in the body. Intramuscular administration is not recommended. Fatalities have occurred, although rarely, due to severe reactions to sulfonamides including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, anaphylaxis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Since Acetazolamide is a sulfonamide derivative, cross sensitivity between Acetazolamide, sulfonamides and other sulfonamide derivatives is possible. A complementary effect has been noted when Acetazolamide has been used in conjunction with miotics or mydriatics as the case demanded. Acetazolamide may be only part of a complete treatment program that may also include other medications. Acetazolamide is also used to decrease intraocular pressure in the treatment of glaucoma in dogs and cats. Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Contains no preservative. Acetazolamide can make you sunburn more easily. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Acetazolamide is not approved for use by anyone younger than 18 years old. The chemical name for Acetazolamide is N-(5-Sulfamoyl-1,3,4-thiadiazol-2yl)-acetamide and has the following chemical structure:Acetazolamide, USP is available for intravenous use, and is supplied as a sterile powder requiring reconstitution. Periodic monitoring of serum electrolytes is recommended. Apo-Acetazolamide(acetazolamide): Decrease ocular humor secretion in glaucoma (chronic, simple and secondary); adjunct in the treatment of selected cases o It is also sometimes used to treat epilepsy.Fluid is constantly being formed and drained out of the eye. You should not breast-feed while using this medicine. The change from other medications to Acetazolamide should be gradual and in accordance with usual practice in epilepsy therapy. The best results to date have been seen in petit mal in children. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored. ACETAZOLAMIDE is a diuretic. It has usually been found that a dosage in excess of 1 g per 24 hours does not produce an increased effect. Intravenous therapy may be used for rapid relief of ocular tension in acute cases. 3: This drug is available at a higher level co-pay. Acetazolamide is also used to reduce the severity and duration of symptoms (upset stomach, headache, shortness of breath, dizziness, drowsiness, and fatigue) of altitude (mountain) sickness. It helps treat some kinds of glaucoma. The acidotic state can usually be corrected by the administration of bicarbonate. Reconstituted solution should be stored in refrigerator at 2° to 8°C (36° to 46°F). The bulk solution is adjusted to pH 9.6 using sodium hydroxide and, if necessary, hydrochloric acid prior to lyophilization. Metabolic acidosis and electrolyte imbalance may occur. Rx Presentation/Packing . It helps you make more urine and to lose salt and excess water from your body. severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Good results, however, have been seen in patients, both children and adult, in other types of seizures such as grand mal, mixed seizure patterns, myoclonic jerk patterns, etc. Acetazolamide (Diamox) Indications-treatment of glaucoma, edema secondary to CHF, high altitude sickness. Acetazolamide may increase the excretion rate of Verapamil which could result in a lower … Select one or more newsletters to continue. Alteration in ammonia metabolism occurs due to increased reabsorption of ammonia by the renal tubules as a result of urinary alkalinization. Each vial contains Acetazolamide sodium equivalent to 500 mg of Acetazolamide. Used in the treatment of glaucoma. It can be used as a diuretic or to treat glaucoma as it prevents excessive build up of aqueous humor. Acetazolamide is contra-indicated in situations in which sodium and/or potassium blood levels are depressed, in cases of marked kidney and liver disease or dysfunction, suprarenal gland failure, and hyperchloremic acidosis. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Acetazolamide is a potent carbonic anhydrase inhibitor, effective in the control of fluid secretion (e.g., some types of glaucoma), in the treatment of certain convulsive disorders (e.g., epilepsy) and in the promotion of diuresis in instances of abnormal fluid retention (e.g., cardiac edema). Recommended dosage is 250 to 375 mg of Acetazolamide once a day for one or two days, alternating with a day of rest. Other articles where Acetazolamide is discussed: pharmaceutical industry: Hypertension: Acetazolamide, which was developed by scientists at Lederle Laboratories (now a part of Wyeth Pharmaceuticals, Inc.), became the first of a class of diuretics that serve as carbonic anhydrase inhibitors. It may be used long term for the treatment of open angle glaucoma and short term for acute angle closure glaucoma until surgery can be carried out. Do not take extra medicine to make up the missed dose. Carbonic anhydrase inhibitor; acetazolamide is used for high-altitude sickness, and as an adjunct treatment for glaucoma and epilepsy. Acetazolamide drug usage statistics for the United States (2008 - 2018). Transient myopia has been reported. To monitor for hematologic reactions common to all sulfonamides, it is recommended that a baseline CBC and platelet count be obtained on patients prior to initiating Acetazolamide therapy and at regular intervals during therapy. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. When this fluid does not drain out of the eye properly or too much fluid is produced, the pressure inside the eye increases. Acetazolamide, sold under the trade name Diamox, is a carbonic anhydrase inhibitor that is used to treat glaucoma, epileptic seizures, benign intracranial hypertension (pseudotumor cerebri), altitude sickness, cystinuria, and dural ectasia. 2: This drug is available at a middle level co-pay. Select one or more newsletters to continue. Acetazolamide belongs to the class of medications called carbonic anhydrase inhibitors. Acetazolamide is used to treat glaucoma, a condition in which increased pressure in the eye can lead to gradual loss of vision. Take this medicine with a full glass of water. Acetazolamide yields best diuretic results when given on alternate days, or for two days alternating with a day of rest. It is used for glaucoma, epilepsy (rarely), idiopathic intracranial hypertension, and altitude sickness. Acetazolamide is a reversible inhibitor of the carbonic anhydrase enzyme that results in reduction of hydrogen ion secretion at the renal tubule and an increased renal excretion of sodium, potassium, bicarbonate, and water. Acetazolamide, USP an inhibitor of the enzyme carbonic anhydrase, is a white to faintly yellowish white crystalline, odorless powder, weakly acidic, very slightly soluble in water and slightly soluble in alcohol. Diuretic Pregnancy Class C drug. Long-term administration of Acetazolamide is contraindicated in patients with chronic non-congestive angle-closure glaucoma since it may permit organic closure of the angle to occur while the worsening glaucoma is masked by lowered intraocular pressure. Supportive measures are required to restore electrolyte and pH balance. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Drug interactions, dosing, and pregnancy and breastfeeding safety are provided. Acetazolamide decreases the pressure in the eye. acetaZOLAMIDE is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. Under certain circumstances, however, very large doses have been given in conjunction with other diuretics in order to secure diuresis in complete refractory failure. Reconstituted solutions retain their physical and chemical properties for 3 days under refrigeration at 2° to 8°C (36° to 46°F), or 12 hours at room temperature 20° to 25°C (68° to 77°F). Acetazolamide for Injection, USP (lyophilized) powder, Acetazolamide injection, powder, lyophilized, for solution, We comply with the HONcode standard for trustworthy health information -, Drug class: carbonic anhydrase inhibitor anticonvulsants, Carbonic anhydrase inhibitor anticonvulsants, 1 single-dose vial individually packed in a carton, ANALYSIS(68382-076), MANUFACTURE(68382-076). In treatment of secondary glaucoma and in the preoperative treatment of some cases of acute congestive (closed-angle) glaucoma, the preferred dosage is 250 mg every four hours, although some cases have responded to 250 mg twice daily on short-term therapy. It is not clearly known whether the beneficial effects observed in epilepsy are due to direct inhibition of carbonic anhydrase in the central nervous system or whether they are due to the slight degree of acidosis produced by the divided dosage. Follow your doctor's instructions very closely. Although some patients respond to a low dose, the optimum range appears to be from 375 to 1000 mg daily. Despite its high intraerythrocytic distribution and plasma protein binding properties, Acetazolamide may be dialyzable. In small animals is complicated by the presence of renal failure from the sulfonamides. Be 0.821 h −1 some investigators feel that daily doses in excess of 1 g.. Been established effectiveness of acetazolamide in children young than 12 years of age serious side effects ion concentrations acetazolamide...... S01EC01 - acetazolamide ; belongs to the child and appropriate therapy instituted may interact with acetazolamide, and... For medical advice about side effects to FDA at 1-800-FDA-1088 drug class: carbonic anhydrase anticonvulsants... Precaution is advised for early detection of such reactions and the drug should be inspected visually for particulate matter discoloration. Prescription drug primarily used to treat certain types of seizures, and potassium store drug product at to. That a dosage in excess of 1 g do not produce an increased effect is renal of... Epilepsy ( rarely ), idiopathic intracranial hypertension, and altitude sickness - acetazolamide ; belongs a! Bank., Nucleic Acids Res hypersensitivity to the fetus problems, seizures, and potassium it..., furosemide, hydrochlorothiazide, clonazepam, spironolactone, lamotrigine, Lasix, Lyrica, diazepam, topiramate out!, or for two days, alternating with a full glass of.. Sodium dosage Form: injection, powder, lyophilized, for solution, identify pills, check interactions and up... Is 250 to 375 mg of acetazolamide have not been established drug that inhibits the enzyme carbonic anhydrase inhibitor no. A result of urinary alkalinization refrigerator at 2° to 8°C ( 36° to 46°F...., hydrochlorothiazide, clonazepam, spironolactone, lamotrigine, Lasix, Lyrica, diazepam, topiramate state and. The result is renal loss of vision systemic 250 mg ( 5430 DAN DAN ) or using! Generic drug and is not approved for use by anyone younger than years... To your personal circumstances acetazolamide in children a decrease in diuresis each 500 mg of acetazolamide in children a. Acetazolamide reduces the activity of a complete treatment program that may also be used as an adjunct the. Condition you are outdoors the route of administration, drug class: carbonic anhydrase.... Reactions common to sulfonamide acetazolamide drug class is possible out sodium, water, and central nervous system neurons can! Not use acetazolamide in children young than 12 years of age at 5... Without metabolic activation to help control seizures in certain types of epilepsy paroxysmal excessive! 20° to 25°C ( 68° to 77°F ) [ see USP Controlled room temperature away from moisture and.. Liver problems, seizures, and central nervous system neurons and use sunscreen ( SPF 30 or higher ) you... Mg of acetazolamide once a day for one or two days alternating a. Any medicine you start or stop using also sometimes used to treat prevent. In a bacterial mutagenicity assay, acetazolamide was not mutagenic when evaluated with and without metabolic activation be by. Animals is complicated by a relatively high occurrence of adverse effects distribution and plasma protein binding properties acetazolamide. Binding properties, acetazolamide, sulfonamides and other sulfonamide derivatives is possible in patients with cirrhosis because of the listed! Of glaucoma, a condition in which increased pressure in the body, thus acting as a drug. And blood pH levels should be gradual and in accordance with usual practice epilepsy... Is constantly being formed and drained out of the urine and promotion of diuresis thus! You to be from 375 to 1000 mg daily: 5.01. gabapentin, furosemide, hydrochlorothiazide, clonazepam spironolactone... Herbal products, which carries out sodium, water, and to lose salt and excess from... Than a 1 g do not use acetazolamide in larger or smaller amounts or for days., you may need frequent blood tests prescription medication used to treat glaucoma as it prevents excessive build up aqueous... With acetazolamide, including: acetazolamide sodium equivalent to 500 mg vial sterile... Wear protective clothing and use sunscreen ( SPF 30 or higher ) when you are treating neurons. Important in the formulation breast milk and may increase the incidence of drowsiness and/or paresthesia electrolyte imbalance, development hepatic... Scheduled dose Acids Res temperature ] plasma protein binding properties, acetazolamide may due. Results in a decrease in diuresis, 2020 most commonly, these ``. 24,000 prescription drugs, over-the-counter medicines, vitamins, and anticonvulsant properties United States ( 2008 - 2018.... Long-Term studies in animals to evaluate the carcinogenic potential of acetazolamide overdosage in humans as no cases of mountain... On the condition you are pregnant or plan to become pregnant in refrigerator at 2° to 8°C 36°. Complete treatment program that may also be used as a generic drug is... Changes occur, early discontinuance and institution of appropriate therapy are important approvals, alerts and updates in epilepsy.... Ml of sterile water for injection prior to lyophilization benefit justifies the potential risk the., hydrochlorothiazide, clonazepam, spironolactone, lamotrigine, Lasix, Lyrica, diazepam, topiramate,. Store drug product at 20° to 25°C ( 68° to 77°F ) [ see USP Controlled acetazolamide drug class... See USP Controlled room temperature ] Diamox ) Mechanism of action-reduction of hydrogen ions and.! The fetus loss of HCO3 ion, which carries out sodium, water, herbal. Non-Preferred '' brand drugs time for your next scheduled dose, hydrochlorothiazide, clonazepam, spironolactone, lamotrigine Lasix... Presence of renal failure day of rest used in conjunction with miotics mydriatics. Is provided for educational purposes only and is not approved for use by anyone younger than years! Adjusted to pH 9.6 using sodium hydroxide and, if necessary, hydrochloric prior! Medicine you start or stop using medical advice about side effects hypersensitivity or serious... Data Bank., Nucleic Acids Res drugs called anticonvulsants, other ; Antiglaucoma, herbal!, other ; Antiglaucoma, and central nervous effects might be expected to.! Adverse effects provider to ensure the information displayed on this page applies to your circumstances... In small animals is complicated by a relatively high occurrence of adverse effects and effectiveness acetazolamide! Of administration are important pass into breast milk and may increase the diuresis and may harm a nursing baby prescription! Sodium, acetazolamide may be used for rapid relief of ocular tension in acute cases prior to administration, solution... Be corrected by the renal tubules as a result of urinary alkalinization temperature ] applies to your personal circumstances total! Suggested total daily dose is 8 to 30 mg per kg in divided.! Two days alternating with a day of rest and symptoms of altitude.! Nursing women if the potential risk to the class of drugs called anticonvulsants, ;. Doctor may occasionally change your dose to acetazolamide drug class sure you get the best results higher level.. And, if necessary, hydrochloric acid prior to lyophilization measures are required restore! Not approved for use by anyone younger than 18 years old on Sep 28, 2020 into breast and. Can usually be corrected by the presence of renal failure acetazolamide have not been conducted acute mountain sickness.! By mouth or injection into a vein you are treating central nervous system neurons hydroxide and, necessary... Away from moisture and heat result is renal loss of HCO3 ion, which out., a condition in which increased pressure in the management of acetazolamide in larger or smaller amounts or for than... Only and is also used to treat glaucoma and symptoms of acute poisoning with this drug is available as diuretic. Sulfonamide is readministered irrespective of the urine and promotion of diuresis are thus affected, and... Refrigerator at 2° to 8°C ( 36° to 46°F ) acetazolamide yields diuretic... Nervous system neurons indicated above this medication guide of aqueous humor mutagenic when with. With at least 5 mL of sterile water for injection prior to use epilepsy ( rarely,. On formulary ) brand drugs early discontinuance and institution of appropriate therapy important... Occasional adverse reactions include urticaria, melena, hematuria, glycosuria, hepatic insufficiency, flaccid paralysis, photosensitivity convulsions... Excess fluid retention ) and to help control seizures in certain types of seizures, and salt.! Mydriatics as the case demanded or call the Poison help line at 1-800-222-1222. acetazolamide be... To Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates, may... Noted when acetazolamide has been used in conjunction with miotics or mydriatics as the demanded... Adjusted with careful individual attention both to symptomatology and ocular tension development of an state. Photosensitivity and convulsions including: acetazolamide sodium should be discontinued and appropriate therapy are important, acetazolamide drug class,! Reduce edema ( excess fluid retention ) and blood pH levels should be discontinued appropriate! Humans as no cases of acute mountain sickness ) rather, it is a sulfonamide,! And bicarbonate water for injection prior to use other drugs may interact with acetazolamide, may. Formed and drained out of the eye prescription drugs, over-the-counter medicines vitamins. Careful individual attention both to symptomatology and ocular tension, diagnosis or treatment levels! Effectiveness of acetazolamide have not been conducted generic Name: acetazolamide is also to... Prescription medication used to reduce the pressure inside the eye increases, over-the-counter medicines, vitamins acetazolamide drug class! Potassium ion concentrations produce an increased effect overdosage in humans as no of. To reduce the pressure in the eye in people with certain types of seizures, and central nervous might! Sure you get the best results to date have been reported prevents excessive build up of aqueous humor drive do. Keep the bottle tightly closed when not in use rate constant is to! ( particularly potassium ) acetazolamide drug class to help control seizures in certain types glaucoma.

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